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Herpesvirus exploitation of host immune inhibitory pathways

Stack, Gabrielle, Stacey, Maria A. and Humphreys, Ian R. 2012. Herpesvirus exploitation of host immune inhibitory pathways. Viruses 4 (12) , pp. 1182-1201. 10.3390/v4081182

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Abstract

Herpesviruses employ a plethora of mechanisms to circumvent clearance by host immune responses. A key feature of mammalian immune systems is the employment of regulatory pathways that limit immune responsiveness. The primary functions of these mechanisms are to control autoimmunity and limit exuberant responses to harmless antigen in mucosal surfaces. However, such pathways can be exploited by viral pathogens to enable acute infection, persistence and dissemination. Herein, we outline the current understanding of inhibitory pathways in modulating antiviral immunity during herpesvirus infections in vivo and discuss strategies employed by herpesviruses to exploit these pathways to limit host antiviral immunity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR355 Virology
R Medicine > R Medicine (General)
Uncontrolled Keywords: herpesvirus; immune suppression; IL-10; CD200; PD-1; BTLA; cytomegalovirus
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1999-4915/ (accessed 20/02/2014).
Publisher: MDPI AG
ISSN: 1999-4915
Date of First Compliant Deposit: 30 March 2016
Last Modified: 10 Oct 2017 14:55
URI: http://orca.cf.ac.uk/id/eprint/43232

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Cited 6 times in Web of Science. View in Web of Science.

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