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Pharmacology of ryanodine receptors and Ca2+-induced Ca2+ release

Thomas, Nia Lowri and Williams, Alan John 2012. Pharmacology of ryanodine receptors and Ca2+-induced Ca2+ release. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 1 (4) , pp. 383-397. 10.1002/wmts.34

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Ryanodine receptors (RyR) are cation-selective, ligand-modulated, ion channels that provide a pathway for the regulated release of Ca2+ from intracellular reticular storage organelles to initiate a wide variety of cellular processes. In addition to regulation by endogenous ligands, the function of RyR can be altered by many pharmacological agents. Some of these have been used to establish the contribution of RyR-mediated Ca2+ release to diverse signaling processes. Altered RyR function also plays a role in the development of diseases of both skeletal and cardiac muscles, hence both new and established compounds have potential as RyR-focussed therapeutic agents.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: John Wiley & Sons
ISSN: 2190-460X
Last Modified: 12 Jun 2019 02:29

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