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The use of rodent skilled reaching as a translational model for investigating brain damage and disease

Klein, Alexander, Sacrey, Lori-Ann R., Whishaw, Ian Q. and Dunnett, Stephen Bruce 2012. The use of rodent skilled reaching as a translational model for investigating brain damage and disease. Neuroscience and Behavioural Reviews 36 (3) , pp. 1030-1042. 10.1016/j.neubiorev.2011.12.010

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Abstract

Neurological diseases, including Parkinson's disease, Huntington's disease, and brain damage caused by stroke, cause severe motor impairments. Deficits in hand use are one of the most debilitating motor symptoms and include impairments in body posture, forelimb movements, and finger shaping for manipulating objects. Hand movements can be formally studied using reaching tasks, including the skilled reaching task, or reach-to-eat task. For skilled reaching, a subject reaches for a small food item, grasps it with the fingers, and places it in the mouth for eating. The human movement and its associated deficits can be modeled by experimental lesions to the same systems in rodents which in turn provide an avenue for investigating treatments of human impairments. Skilled reaching movements are scored using three methods: (1) end point measures of attempts and success, (2) biometric measures, and (3) movement element rating scales derived from formal descriptions of movement. The striking similarities between human and rodent reaching movements allow the analysis of the reach-to-eat movement to serve as a powerful tool to generalize preclinical research to clinical conditions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QR Microbiology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Parkinson's disease; Huntington's disease; Stroke; Staircase test; Single pellet reaching test; Motor impairments; Motor test; Behavior; Reach-to-eat
Publisher: Elsevier
ISSN: 0149-7634
Last Modified: 04 Jun 2017 04:43
URI: http://orca.cf.ac.uk/id/eprint/43567

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