Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Sulcal and gyral crown cortical grey matter involvement in multiple sclerosis: A magnetisation transfer ratio study

Samson, R. S., Muhlert, Nils ORCID: https://orcid.org/0000-0002-6414-5589, Sethi, V., Wheeler-Kingshott, C. A. M., Ron, M. A., Miller, D. H. and Shard, D. T. 2013. Sulcal and gyral crown cortical grey matter involvement in multiple sclerosis: A magnetisation transfer ratio study. Multiple Sclerosis and Related Disorders 2 (3) , pp. 204-212. 10.1016/j.msard.2013.01.001

Full text not available from this repository.

Abstract

Background: Histopathology has demonstrated extensive cortical grey matter (GM) demyelination in multiple sclerosis (MS), and suggests that sulcal folds may be preferentially affected, particularly in progressive MS. This has not been confirmed in vivo, and it is not known if it is relevant to clinical status. Objectives: To determine sulcal and gyral crown magnetisation transfer ratio (MTR) in MS cortical GM, and the MTR associations with clinical status. Methods: We measured sulcal and gyral crown cortical GM MTR values in 61 MS patients and 32 healthy controls. Disability was measured using Expanded Disability Status Scale and Multiple Sclerosis Functional Composite scores. Results: MTR values were reduced in sulcal and gyral crown regions in all MS subtypes, more so in secondary progressive (SP) MS than relapsing remitting (RR) MS, and similarly in primary progressive (PP) MS and RRMS. Sulcal MTR was lower than gyral crown MTR in controls, PPMS and RRMS patients, but not in SPMS. MTR correlated with clinical status in RRMS and SPMS, but not PPMS. Conclusions: Cortical pathology, as reflected by MTR, is present in all MS subtypes and most pronounced in SPMS. A preferential disease effect on sulcal cortical regions was not observed. Cortical MTR abnormalities appear to be more clinically relevant in relapse-onset rather than progressive-onset MS.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Multiple sclerosis; Magnetisation transfer ratio; Cortical grey matter; MRI; Sulcal; Gyral crown
Publisher: Elsevier
ISSN: 2211-0348
Last Modified: 24 Oct 2022 10:15
URI: https://orca.cardiff.ac.uk/id/eprint/43606

Citation Data

Cited 4 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item