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Endothelial function and coagulant factors in growth hormone-treated hypopituitary adults receiving desmopressin

Smith, Jamie Christina, Lane, Helen A., Lewis, J., Dann, S., Goodfellow, Jonathan, Collins, Peter William, Evans, L. M., Scanlon, Maurice Francis and Davies, J. S. 2003. Endothelial function and coagulant factors in growth hormone-treated hypopituitary adults receiving desmopressin. Journal of Clinical Endocrinology & Metabolism 88 (5) , pp. 2152-2156. 10.1210/jc.2002-021618

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Abstract

Although GH deficiency may underlie the increased cardiovascular risk in adult hypopituitarism, other coexisting hormonal deficiencies and/or unphysiological hormone replacement may contribute. L-Deamino-8-D-arginine (DDAVP), when administered parenterally, potentiates hemostasis by increasing plasma procoagulant factors. We investigated whether chronic intranasal DDAVP therapy influences clotting factors (plasma fibrinogen, factor VIII, and von Willebrand factor antigen) and endothelial function (flow-mediated dilation of the brachial artery) in 30 GH-treated hypopituitary subjects, including both DDAVP-treated subjects (group A) (mean age, 46

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
ISSN: 0021-972X
Last Modified: 04 Jun 2017 01:32
URI: http://orca.cf.ac.uk/id/eprint/437

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