Retinal photodamage

Boulton, Michael Edwin, Rozanowska, Malgorzata Barbara ORCID: https://orcid.org/0000-0003-2913-8954 and Rozanowski, B. 2001. Retinal photodamage. Journal of Photochemistry and Photobiology B: Biology 64 (2-3) , pp. 144-161. 10.1016/S1011-1344(01)00227-5

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Abstract

The retina represents a paradox, in that, while light and oxygen are essential for vision, these conditions also favour the formation of reactive oxygen species leading to photochemical damage to the retina. Such light damage seems to be multi-factorial and is dependent on the photoreactivity of a variety of chromophores (e.g., vitamin A metabolites, lipofuscin, melanin, flavins, porphyrins, carotenoids) endogenous to the retina. The aim of this article is to provide a detailed review of our current understanding of the photochemistry and photobiology of these chromophores and to consider how they may contribute to retinal ageing and pathology.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Subjects:	R Medicine > RE Ophthalmology
Uncontrolled Keywords:	Retina; Light damage; Retinal; Melanin; Lipofuscin; Macular pigment
Publisher:	Elsevier
ISSN:	1011-1344
Last Modified:	24 Oct 2022 10:23
URI:	https://orca.cardiff.ac.uk/id/eprint/44140

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