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Preservative activity in diluted corticosteroid creams

Hugo, W. B., Denyer, Stephen Paul, York, H. L. and Tucker, J. D. 1984. Preservative activity in diluted corticosteroid creams. Journal of Hospital Infection 5 (3) , pp. 329-333. 10.1016/0195-6701(84)90083-5

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The preservative efficacy of both ‘Betnovate’ and ‘Synalar’ creams diluted 1:1 with ‘Unguentum Merck’ was investigated. Each formulation was challenged with Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa at an initial inoculum level of approximately 1 × 106 viable organisms per gram of cream. All formulations tested were found to be effectively preserved against the organisms used and no viable bacteria were detected 7 days after inoculation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: Elsevier
ISSN: 0195-6701
Last Modified: 19 Mar 2016 23:14

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