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Resistance and cross-resistance to oxidising agents of bacterial isolates from endoscope washer disinfectors

Martin, D. J. H., Denyer, Stephen Paul, McDonnell, G. and Maillard, Jean-Yves 2008. Resistance and cross-resistance to oxidising agents of bacterial isolates from endoscope washer disinfectors. Journal of Hospital Infection 69 (4) , pp. 377-383. 10.1016/j.jhin.2008.04.010

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Bacteria isolated from washer disinfectors using chlorine dioxide as a high-level disinfectant were exposed to peracetic acid, chlorine dioxide and hydrogen peroxide to investigate their susceptibility and possible bacterial cross-resistance to these highly reactive oxidising biocides. A standard suspension test was used to establish a rate of kill of these biocides against two stable isolates (Bacillus subtilis and Micrococcus luteus). Suspension tests demonstrated that ‘in use’ concentrations were not always effective to provide the required disinfection efficacy within recommended exposure times and in some instances a 60 min exposure was necessary to achieve a reduction in number by a factor of 105. It appears that vegetative Gram-positive isolates can become resistant to oxidising agents in vitro, and that cross-resistance to related compounds can occur. Since these bacteria are deemed to be susceptible to highly reactive biocides, there should be further study of the resistance mechanisms in these isolates to explain their survival.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Cross-resistance; Endoscopes; Cleaning; Washer disinfectors; Disinfectants
Publisher: Elsevier
ISSN: 0195-6701
Last Modified: 04 Jun 2017 04:46

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