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The psychological side effects of acebutolol and atenolol

Lewis, M. J., Jones, Dylan Marc, Dart, A. M. and Henderson, A. H. 1984. The psychological side effects of acebutolol and atenolol. British Journal Of Clinical Pharmacology 17 (3) , pp. 364-366. 10.1111/j.1365-2125.1984.tb02356.x

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We have measured the psychological effects of acebutolol and atenolol in sixteen patients with essential hypertension. The drugs were administered in a randomized, placebo-controlled, double-blind manner, in single daily doses of 100 mg atenolol, 400 mg acebutolol or placebo for periods of 6 weeks, each drug period being separated by a placebo period. At each 2 weekly clinic visit, a questionnaire designed for assessment of state anxiety and state arousal was administered for self- completion. Arousal was significantly reduced by atenolol over the whole 6 weeks of administration. It was not affected by acebutolol. Anxiety was significantly reduced by acebutolol but only at the first of the three 2 weekly assessments on treatment. It was not affected by atenolol. Differences in the psychological effects of these two beta- adrenoceptor blockers are discussed in terms of their lipid solubility and haemodynamic effects.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RM Therapeutics. Pharmacology
Publisher: Blackwell Publishing
ISSN: 0306-5251
Last Modified: 14 Dec 2020 09:53

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