Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells

Bagley, Mark Christopher, Davis, Terence, Dix, Matthew, Rokicki, Michal Jaroslaw and Kipling, David Glyn 2007. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. Biorganic and Medicinal Chemistry Letters 17 (18) , pp. 5107-5110. 10.1016/j.bmcl.2007.07.016

Full text not available from this repository.


The p38 mitogen-activated protein kinase inhibitor VX-745 is prepared rapidly and efficiently in a four-step sequence using a combination of conductive heating and microwave-mediated steps. Its inhibitory activity was confirmed in hTERT immortalized HCA2 and WS dermal fibroblasts at 0.5–1.0 μM concentration by ELISA and immunoblot assay, and displays excellent kinase selectivity over the related stress-activated kinase JNK.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
R Medicine > RB Pathology
Uncontrolled Keywords: p38 MAPK; Werner syndrome; VX-745; Microwaves; Heterocycles; Ullmann coupling; Palladium
Publisher: Elsevier
ISSN: 0960-894X
Last Modified: 04 Jun 2017 04:56

Citation Data

Cited 45 times in Google Scholar. View in Google Scholar

Cited 40 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item