Profiles of inflammatory cytokines following colorectal surgery: relationship with wound healing and outcome

Baker, Elizabeth A., El-Gaddal, Sanaa, Williams, Lynne and Leaper, David J. 2006. Profiles of inflammatory cytokines following colorectal surgery: relationship with wound healing and outcome. Wound Repair and Regeneration 14 (5) , pp. 566-572. 10.1111/j.1743-6109.2006.00163.x

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Abstract

Inflammation is an essential component of normal wound healing. This study has correlated systemic (plasma) and local (wound fluid) concentrations of inflammatory cytokines (interleukin [IL]-6, tumor necrosis factor-α [TNF-α], and IL-1β) with wound healing and surgical outcome following elective colorectal surgery. Paired plasma and wound fluid samples were collected (n=44) postoperatively (days 1, 3, 5, 7) and analyzed by enzyme-linked immunosorbent assay (pg/mL). Cytokine levels were significantly greater in drain fluid than plasma on each postoperative day (POD); e.g., POD 1 : IL-6; drain fluid, median, 77,050 pg/mL (range 9,928–456,408); plasma, 241 pg/mL (22–1,333). Daily profiles of IL-6 and TNF-α were similar in drain fluid and plasma; IL-6 levels peaked on POD 1 decreasing to POD 7, and TNF-α levels increased from PODs 1 to 7. However, IL-1β in plasma peaked on POD 1 and plateaued, whereas drain fluid showed two peaks (PODs 1 and 7). Only plasma levels of cytokines correlated to clinical parameters; IL-6 levels significantly correlated with postoperative complications; e.g., POD 5, complications 92(1–597) and no complications, 14(2–217). IL-6 also correlated with tumor pathology (Dukes stage, tumor depth, vascular invasion), and TNF-α levels correlated with the estimated blood loss during surgery. We conclude that local wound levels of cytokines correlated with the stage of wound healing, whereas systemic levels correlated with postoperative complications and tumor pathology.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley-Blackwell
ISSN:	1524-475X
Last Modified:	19 Mar 2016 22:01
URI:	https://orca.cardiff.ac.uk/id/eprint/476

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