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Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa

Acton, Jennifer H., Greenberg, Jonathan P., Greenstein, Vivienne C., Marsiglia, Marcela, Tabacaru, Mirela, Theodore Smith, R. and Tsang, Stephen H. 2013. Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa. Experimental Eye Research 113 , pp. 41-48. 10.1016/j.exer.2013.05.003

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Abstract

The aim of this study was to investigate visualization of the tapetal-like reflex using current imaging modalities and evaluate SD-OCT changes in known carriers of X-linked retinitis pigmentosa (XLRP); the objective being the development of an optimal protocol for clinicians to identify carriers. Ten XLRP carriers (19 eyes) were examined using color fundus photography, 488 nm reflectance (488-R), near-infrared reflectance (NIR-R), autofluorescence (AF) and spectral domain optical coherence tomography (SD-OCT) imaging (Spectralis SLO-OCT, Heidelberg). Horizontal line scans through the fovea were acquired in all subjects and in a group of 10 age-similar controls. Peripheral SD-OCT scans (extending to 27.5° eccentricity) were also acquired in both eyes of 7 carriers. MP-1 microperimetery (10-2 pattern; Nidek) was performed in one eye of each carrier. For the XLRP carriers, a tapetal reflex was observed with all imaging modalities in 8 of 19 eyes. It had the same retinal location on color fundus, 488-R and NIR-R imaging but a different location on AF. The tapetal reflex was most easily detected in 488-R images. The horizontal foveal SD-OCT scans were qualitatively normal, but measurements showed significant outer retinal layer thinning in all eyes. Additionally, the 14 eyes with peripheral SD-OCTs demonstrated patchy loss of the inner segment ellipsoid band. Microperimetry exhibited patchy visual sensitivity loss in 9 eyes. Full field ERGs were variable, ranging from normal to severely abnormal rod and cone responses. Our findings suggest that an optimal protocol for identifying carriers of XLRP should include 488-R imaging in a multimodal approach. Peripheral SD-OCT imaging and central retinal layer quantification revealed significant structural abnormalities.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: X-linked retinitis pigmentosa; tapetal-like reflex; spectral domain optical coherence tomograph; scanning laser ophthalmoscope; microperimetry
Publisher: Elsevier
ISSN: 0014-4835
Last Modified: 02 May 2019 13:34
URI: http://orca.cf.ac.uk/id/eprint/48084

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