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Modeling accuracy and variability of motor timing in treated and untreated Parkinson's disease and healthy controls

Jones, Catherine R. G., Claassen, Daniel O., Yu, Minhong, Spies, Jeffrey R., Malone, Tim, Dirnberger, Georg, Jahanshahi, Marjan and Kubovy, Michael 2011. Modeling accuracy and variability of motor timing in treated and untreated Parkinson's disease and healthy controls. Frontiers in Integrative Neuroscience 5 , 81. 10.3389/fnint.2011.00081

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Abstract

Parkinson’s disease (PD) is characterized by difficulty with the timing of movements. Data collected using the synchronization–continuation paradigm, an established motor timing paradigm, have produced varying results but with most studies finding impairment. Some of this inconsistency comes from variation in the medication state tested, in the inter-stimulus intervals (ISI) selected, and in changeable focus on either the synchronization (tapping in time with a tone) or continuation (maintaining the rhythm in the absence of the tone) phase. We sought to re-visit the paradigm by testing across four groups of participants: healthy controls, medication naïve de novo PD patients, and treated PD patients both “on” and “off” dopaminergic medication. Four finger tapping intervals (ISI) were used: 250, 500, 1000, and 2000 ms. Categorical predictors (group, ISI, and phase) were used to predict accuracy and variability using a linear mixed model. Accuracy was defined as the relative error of a tap, and variability as the deviation of the participant’s tap from group predicted relative error. Our primary finding is that the treated PD group (PD patients “on” and “off” dopaminergic therapy) showed a significantly different pattern of accuracy compared to the de novo group and the healthy controls at the 250-ms interval. At this interval, the treated PD patients performed “ahead” of the beat whilst the other groups performed “behind” the beat. We speculate that this “hastening” relates to the clinical phenomenon of motor festination. Across all groups, variability was smallest for both phases at the 500-ms interval, suggesting an innate preference for finger tapping within this range. Tapping variability for the two phases became increasingly divergent at the longer intervals, with worse performance in the continuation phase. The data suggest that patients with PD can be best discriminated from healthy controls on measures of motor timing accuracy, rather than variability.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: motor timing, Parkinson’s disease, temporal processing, synchronization, continuation, dopamine, linear mixed model
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1662-5145/ (accessed 25/02/2014). This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
Publisher: Frontiers Research Foundation
ISSN: 1662-5145
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 05:06
URI: http://orca.cf.ac.uk/id/eprint/48425

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