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Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

Patel, Onisha, Pellicci, Daniel G., Gras, Stephanie, Sandoval-Romero, Maria L., Uldrich, Adam P., Mallevaey, Thierry, Clarke, Andrew J., Le Nours, Jérôme, Theodossis, Alex, Cardell, Susanna L., Gapin, Laurent, Godfrey, Dale I. and Rossjohn, Jamie 2012. Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nature Immunology 13 (9) , pp. 857-863. 10.1038/ni.2372

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Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen receptor (TCR) repertoire and CD1d-antigen specificity. Although the mode by which type I NKT cell TCRs recognize CD1d-antigen has been established, how type II NKT cell TCRs engage CD1d-antigen is unknown. Here we provide a basis for how a type II NKT cell TCR, XV19, recognized CD1d-sulfatide. The XV19 TCR bound orthogonally above the A′ pocket of CD1d, in contrast to the parallel docking of type I NKT cell TCRs over the F′ pocket of CD1d. At the XV19 TCR–CD1d-sulfatide interface, the TCRα and TCRβ chains sat centrally on CD1d, where the malleable CDR3 loops dominated interactions with CD1d-sulfatide. Accordingly, we highlight the diverse mechanisms by which NKT cell TCRs can bind CD1d and account for the distinct antigen specificity of type II NKT cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology > QR180 Immunology
Publisher: Nature Publishing Group
ISSN: 1529-2908
Last Modified: 04 Jun 2017 05:06

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