Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

Davies, Luke Cynlais, Rosas, Marcela, Jenkins, Stephen J., Liao, Chia-Te, Scurr, Martin John, Brombacher, Frank, Fraser, Donald James, Allen, Judith E., Jones, Simon Arnett and Taylor, Philip Russel 2013. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications 4 , 1886. 10.1038/ncomms2877

Full text not available from this repository.

Abstract

The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived inflammatory and tissue-resident macrophage lineage branches is a key feature of the inflammatory process with major implications for the mechanisms underlying recovery from inflammation. Both macrophage lineage branches are dependent on M-CSF during inflammation, and thus the potential for therapeutic interventions is marked. Furthermore, these observations are independent of Th2 immunity. These studies indicate that the proliferation of distinct macrophage populations provides a general mechanism for macrophage expansion at key stages during inflammation, and separate control mechanisms are implicated.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: Nature Publishing Group
ISSN: 2041-1723
Last Modified: 13 Apr 2019 21:24
URI: http://orca.cf.ac.uk/id/eprint/48470

Citation Data

Cited 53 times in Google Scholar. View in Google Scholar

Cited 136 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 61 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item