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Intrapartum tests for group B streptococcus: accuracy and acceptability of screening

Daniels, J. P., Gray, J., Pattison, H. M., Gray, R., Hills, Robert Kerrin and Khan, K. S. 2011. Intrapartum tests for group B streptococcus: accuracy and acceptability of screening. BJOG-an International Journal of Obstetrics and Gynaecology 118 (2) , pp. 257-265. 10.1111/j.1471-0528.2010.02725.x

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Objective:  To assess the accuracy and acceptability of polymerase chain reaction (PCR) and optical immunoassay (OIA) tests for the detection of maternal group B streptococcus (GBS) colonisation during labour, comparing their performance with the current UK policy of risk factor-based screening. Design:  Diagnostic test accuracy study. Setting and population:  Fourteen hundred women in labour at two large UK maternity units provided vaginal and rectal swabs for testing. Methods:  The PCR and OIA index tests were compared with the reference standard of selective enriched culture, assessed blind to index tests. Factors influencing neonatal GBS colonisation were assessed using multiple logistic regression, adjusting for antibiotic use. The acceptability of testing to participants was evaluated through a structured questionnaire administered after delivery. Main outcome measures:  The sensitivity and specificity of PCR, OIA and risk factor-based screening. Results:  Maternal GBS colonisation was 21% (19–24%) by combined vaginal and rectal swab enriched culture. PCR test of either vaginal or rectal swabs was more sensitive (84% [79–88%] versus 72% [65–77%]) and specific (87% [85–89%] versus 57% [53–60%]) than OIA (P < 0.001), and far more sensitive (84 versus 30% [25–35%]) and specific (87 versus 80% [77–82%]) than risk factor-based screening (P < 0.001). Maternal antibiotics (odds ratio, 0.22 [0.07–0.62]; P = 0.004) and a positive PCR test (odds ratio, 29.4 [15.8–54.8]; P < 0.001) were strongly related to neonatal GBS colonisation, whereas risk factors were not (odds ratio, 1.44 [0.80–2.62]; P = 0.2). Conclusion: Intrapartum PCR screening is a more accurate predictor of maternal and neonatal GBS colonisation than is OIA or risk factor-based screening, and is acceptable to women.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RG Gynecology and obstetrics
Additional Information: Members of the GBS Collaborative Group are listed at the end of the article
Publisher: Wiley-Blackwell
ISSN: 1470-0328
Last Modified: 19 Oct 2019 02:56

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