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Differential regulation of macropinocytosis in macrophages by cytokines: Implications for foam cell formation and atherosclerosis

Michael, Daryn Robert, Ashlin, Timothy Gordon, Davies, Charlotte S., Gallagher, Hayley, Stoneman, Thomas W., Buckley, Melanie and Ramji, Dipak Purshottam 2013. Differential regulation of macropinocytosis in macrophages by cytokines: Implications for foam cell formation and atherosclerosis. Cytokine 64 (1) , pp. 357-361. 10.1016/j.cyto.2013.05.016

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Abstract

A key event during the formation of lipid-rich foam cells during the progression of atherosclerosis is the uptake of modified low-density lipoproteins (LDL) by macrophages in response to atherogenic mediators in the arterial intima. In addition to scavenger receptor-dependent uptake of LDL, macropinocytosis is known to facilitate the uptake of LDL through the constitutive and passive internalization of large quantities of extracellular solute. In this study we confirm the ability of macropinocytosis to facilitate the uptake of modified LDL by human macrophages and show its modulation by TGF-β, IFN-γ, IL-17A and IL-33. Furthermore we show that the TGF-β-mediated inhibition of macropinocytosis is a Smad-2/-3-independent process.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QP Physiology
Uncontrolled Keywords: Macropinocytosis; Cytokine; Foam cell; Atherosclerosis; Low density lipoprotein
Publisher: Elsevier
ISSN: 1043-4666
Date of First Compliant Deposit: 30 March 2016
Last Modified: 13 Sep 2019 21:13
URI: http://orca.cf.ac.uk/id/eprint/49903

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