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The pharmacokinetics of paroxetine in the elderly

Bayer, Antony James, Roberts, N. A., Allen, E. A., Horan, M., Routledge, Philip Alexander, Swift, C. G., Byrne, M. M., Clarkson, A. and Zussman, B. D. 1989. The pharmacokinetics of paroxetine in the elderly. Acta Psychiatrica Scandinavica Supplementum 80 (S350) , pp. 85-86. 10.1111/j.1600-0447.1989.tb07179.x

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Abstract

Paroxetine is a novel phenylpiperidine compound which acts as an antidepressant via specific 5-HT uptake inhibition. The elderly are of particular interest as they constitute a major population requiring antidepressant therapy, and the pharmacokinetics of many drugs are known to change with age. This paper presents the results generated in an investigation of the oral pharmacokinetics of paroxetine in healthy elderly subjects and healthy elderly subjects and healthy young adults after a single 20mg dose and after once-daily dosing with 20mg for 15 consecutive days.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Pharmacokinetics, paroxetine, elderly subjects
Publisher: Wiley
ISSN: 0001-690X
Last Modified: 04 Jun 2017 05:15
URI: http://orca.cf.ac.uk/id/eprint/50104

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