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Analysis of skilled forelimb movement in rats: the single pellet reaching test and staircase test

Klein, Alexander and Dunnett, Stephen Bruce 2012. Analysis of skilled forelimb movement in rats: the single pellet reaching test and staircase test. Current Protocols in Neuroscience 58 , 8.28.1-8.28.15. 10.1002/0471142301.ns0828s58

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Abstract

Brain damage, stroke, and neurodegenerative diseases such as Parkinson's or Huntington's disease can cause severe motor deficits in skilled forelimb use in both humans and rats. These deficits are typically analyzed in a reach-to-eat paradigm. Skilled reaching in rats has been found to be a good model of human skilled reaching. Therefore, rats serve as an excellent tool to monitor the development of deficits after neurological insults or changes after medical intervention. The following protocols comprise two different tests of rat skilled reaching. The single pellet reaching test is a paradigm that involves detailed rating and analysis of qualitative aspects of the reaching movement itself. The staircase test is an objective, high-throughput reaching task that allows reaching success (number of pellets eaten) to be investigated in multiple rats at the same time. Both tests have been used extensively to investigate motor deficits and effects of treatment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
ISSN: 1934-8584
Last Modified: 04 Jun 2017 05:15
URI: http://orca.cf.ac.uk/id/eprint/50130

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