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A novel jet-based nano-hydroxyapatite patterning technique for osteoblast guidance

Li, Xiang, Koller, Garrit, Huang, Jie, Di Silvio, Lucy, Renton, Tara, Esat, Minoo, Bonfield, William and Edirisinghe, Mohan 2010. A novel jet-based nano-hydroxyapatite patterning technique for osteoblast guidance. Journal of the Royal Society Interface 7 (42) , pp. 189-197. 10.1098/rsif.2009.0101

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Surface topography is well known to play a crucial role in influencing cellular responses to an implant material and is therefore important in bone tissue regeneration. A novel jet-based patterning technique, template-assisted electrohydrodynamic atomization spraying, was recently devised to control precisely the surface structure as well as its dimensions. In the present study, a detailed investigation of this patterning process was carried out. A range of nano-hydroxyapatite (nHA) line-shaped patterns ,20 mm in width were successfully deposited on a commercially pure Ti surface by controlling the flow of an nHA suspension in an electric field. In vitro studies showed that the nHA patterns generated are capable of regulating the human osteoblast cell attachment and orientation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Postgraduate Medical and Dental Education
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
Publisher: The Royal Society
ISSN: 1742-5689
Last Modified: 19 Mar 2016 23:24

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