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Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array

Castell, Oliver Kieran, Berridge, James and Wallace, Mark I. 2012. Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array. Angewandte Chemie - International Edition 51 (13) , pp. 3134-3138. 10.1002/anie.201107343

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Abstract

Optical platforms for assaying membrane protein function offer a promising route to scalable high-throughput screening (see picture). For the first time quantitative measurements of membrane protein inhibition are reported in an optically addressable lipid bilayer array. Wide-field total internal reflection fluorescence (TIRF) imaging of Ca2+ flux enables the quantification of α-hemolysin inhibition by γ-cyclodextrin.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: arrays; high-throughput screening; lipid bilayers; membrane proteins
Publisher: Wiley-Blackwell
ISSN: 1433-7851
Last Modified: 04 Jun 2017 05:26
URI: http://orca.cf.ac.uk/id/eprint/51313

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