A controlled trial of two bicarbonate-containing dialysis fluids for CAPD - Final report

Coles, Gerald A., O'Donoghue, D., Pritchard, N., Ogg, C., Jani, F., Gokal, R., Cancarini, G., Maiorca, R., Tranaeus, A., De Vos, C., Hopwood, A. and Faict, D. 1998. A controlled trial of two bicarbonate-containing dialysis fluids for CAPD - Final report. Nephrology Dialysis Transplantation 13 (12) , pp. 3165-3171. 10.1093/ndt/13.12.3165

Full text not available from this repository.

Abstract

BACKGROUND: The combination of a low pH and a high concentration of lactate which is present in most dialysis fluids is found to be cytotoxic in vitro. For these reasons it would seem logical to use a bicarbonate-containing solution and thus automatically provide a solution with a neutral pH. METHODS: A parallel, randomized, open-label, prospective 2-month trial with an optional 4 month extension was undertaken to compare two novel bicarbonate-based solutions; one containing 38 mmol/l of bicarbonate (B), and one containing a mixture of 25 mmol/l bicarbonate and 15 mmol/l of lactate (B/L), with a control solution (C) containing 40 mmol/l lactate. RESULTS: Three groups of 19 (C), 20 (B), and 20 (B/L) patients were recruited and data from approximately 55 patient months were accumulated in each group. The data show that both bicarbonate-based solutions maintain acid-base levels within the normal range, that there were no changes in any of the other blood biochemistry parameters measured in the peritoneal equilibration test or with regard to adequacy of dialysis, and that furthermore, both solutions were well tolerated. CONCLUSIONS: This study showed that either the bicarbonate or bicarbonate/lactate solutions could be utilized efficaciously in patients undergoing CAPD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Additional Information:	Former Cardiff University author: Gerald A. Coles.
Publisher:	Oxford University Press
ISSN:	0931-0509
Last Modified:	27 Nov 2013 14:33
URI:	https://orca.cardiff.ac.uk/id/eprint/52599

Citation Data

Cited 59 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item