Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Frontal white matter integrity is related to psychomotor retardation in major depression

Walther, Sebastian, Hügli, Simone, Höfle, Oliver, Federspiel, Andrea, Horn, Helge, Bracht, Tobias, Wiest, Roland, Strik, Werner and Müller, Thomas J. 2012. Frontal white matter integrity is related to psychomotor retardation in major depression. Neurobiology of Disease 47 (1) , pp. 13-19. 10.1016/j.nbd.2012.03.019

Full text not available from this repository.

Abstract

Altered frontal white matter integrity has been reported in major depression. Still, the behavioral correlates of these alterations are not established. In healthy subjects, motor activity correlated with white matter integrity in the motor system. To explore the relation of white matter integrity and motor activity in major depressive disorder, we investigated 21 medicated patients with major depressive disorder and 21 matched controls using diffusion tensor imaging and wrist actigraphy at the same day. Patients had lower activity levels (AL) compared with controls. Fractional anisotropy (FA) differed between groups in frontal white matter regions and the posterior cingulum. AL was linearly associated with white matter integrity in two clusters within the motor system. Controls had an exclusive positive association of FA and AL in white matter underneath the right dorsal premotor cortex. Only patients had a positive association within the posterior cingulum. Furthermore, patients had negative associations of FA and AL underneath the left primary motor cortex and within the left parahippocampal gyrus white matter. These differences in the associations between structure and behavior may contribute to well-known impaired motor planning or gait disturbances in major depressive disorder. Therefore, signs of psychomotor slowing in major depressive disorder may be linked to changes of the white matter integrity of the motor system.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Uncontrolled Keywords: Motor activity; Actigraphy; Fractional anisotropy; Motor system; Premotor cortex
Publisher: Elsevier
ISSN: 0969-9961
Last Modified: 10 Jan 2018 09:20
URI: http://orca.cf.ac.uk/id/eprint/52727

Citation Data

Cited 19 times in Google Scholar. View in Google Scholar

Cited 52 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item