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IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

Ben-Sasson, S. Z., Hu-Li, J., Quiel, J., Caucheteux, Stephane, Ratner, M., Shapira, I., Dinarello, C. A. and Paul, W. E. 2009. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proceedings of the National Academy of Sciences of the United States of America 106 (17) , pp. 7119-7124. 10.1073/pnas.0902745106

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IL-1 causes a marked increase in the degree of expansion of naïve and memory CD4 T cells in response to challenge with their cognate antigen. The response occurs when only specific CD4 T cells can respond to IL-1β, is not induced by a series of other cytokines and does not depend on IL-6 or CD-28. When WT cells are primed in IL-1R1−/− recipients, IL-1 increases the proportion of cytokine-producing transgenic CD4 T cells, especially IL-17- and IL-4-producing cells, strikingly increases serum IgE levels and serum IgG1 levels. IL-1β enhances antigen-mediated expansion of in vitro primed Th1, Th2, and Th17 cells transferred to IL-1R1−/− recipients. The IL-1 receptor antagonist diminished responses to antigen plus lipopolysaccharide (LPS) by ≈55%. These results indicate that IL-1β signaling in T cells markedly induces robust and durable primary and secondary CD4 responses.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: cytokines; inflammasome; Th1; Th17; Th2
Publisher: National Academy of Sciences
ISSN: 0027-8424
Last Modified: 08 Jan 2020 03:27

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