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Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migration

Caucheteux, Stephane, Torabi-Parizi, P. and Paul, W. E. 2013. Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migration. Proceedings of the National Academy of Sciences of the United States of America 110 (5) , pp. 1821-1826. 10.1073/pnas.1221306110

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The proportion of CD4 T cells with phenotypic and functional properties of naïve cells out of total CD4 T cells is similar in the lung parenchyma and lymph nodes. On treatment with a sphingosine-1-phosphate agonist, the frequency of these cells falls precipitously, but with a delay of ∼14 h compared with blood CD4 T cells; neither anti-CD62L nor pertussis toxin prevents entry of naïve CD4 T cells into the lung. Based on treatment with anti-CD62L and the use of CCR7−/− cells, lung naïve CD4 T cells appear to migrate to the mediastinal lymph nodes along a CD62L-independent, CCR7-dependent pathway. Cells that have entered the node in this manner are competent to respond to antigen. Thus, a portion (approximately one-half) of naïve CD4 T cells appears to enter the mediastinal lymph nodes through a blood-to-lung-to-lymph node route.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: immune response; lymphocyte traffic; pulmonary lymphocyte
Publisher: National Academy of Sciences
ISSN: 0027-8424
Last Modified: 08 Jan 2020 03:28

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