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Developing an international 'Pseudomonas aeruginosa' reference panel

De Soyza, Anthony, Hall, Amanda J., Mahenthiralingam, Eshwar, Drevinek, Pavel, Kaca, Wieslaw, Drulis-Kawa, Zuzanna, Stoitsova, Stoyanka R., Toth, Veronika, Coenye, Tom, Zlosnik, James E. A., Burns, Jane L., Sá-Correia, Isabel, De Vos, Daniel, Pirnay, Jean-Paul, J. Kidd, Timothy, Reid, David, Manos, Jim, Klockgether, Jens, Wiehlmann, Lutz, Tümmler, Burkhard, McClean, Siobhán and Winstanley, Craig 2013. Developing an international 'Pseudomonas aeruginosa' reference panel. MicrobiologyOpen 2 (6) , pp. 1010-1023. 10.1002/mbo3.141

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Abstract

Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
Uncontrolled Keywords: Cystic fibrosis; genotype; pathogen; Pseudomonas aeruginosa
Publisher: Wiley-Blackwell
ISSN: 2045-8827
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 05:50
URI: http://orca.cf.ac.uk/id/eprint/53938

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