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Inhibition among olfactory receptor neurons

Van Der Goes Van Naters, Wynand 2013. Inhibition among olfactory receptor neurons. Frontiers in Human Neuroscience 7 , 690. 10.3389/fnhum.2013.00690

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Abstract

Often assumed to be epiphenomena of a cell’s activity, extracellular currents and resulting potential changes are increasingly recognized to influence the function of other cells in the vicinity. Experimental evidence shows that even small electric fields can modulate spike timing in neurons. Moreover, when neurons are brought close together experimentally or in pathological conditions, activity in one neuron can excite its neighbors. Inhibitory ephaptic mechanisms, however, may depend on more specialized coupling among cells. Recent studies in the Drosophila olfactory system have shown that excitation of a sensory neuron can inhibit its neighbor, and it was speculated that this interaction was ephaptic. Here we give an overview of ephaptic interactions that effect changes in spike timing, excitation or inhibition in diverse systems with potential relevance to human neuroscience. We examine the mechanism of the inhibitory interaction in the Drosophila system and that of the well-studied ephaptic inhibition of the Mauthner cell in more detail. We note that both current towards and current away from the local extracellular environment of a neuron can inhibit it, but the mechanism depends on the specific architecture of each system.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Uncontrolled Keywords: olfaction; inhibition; ephaptic; sensillump; sensory neurons; Drosophila
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1662-5161/ (accessed 25/02/2014). This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
Publisher: Frontiers Research Foundation
ISSN: 1662-5161
Funders: BBSRC
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 05:50
URI: http://orca.cf.ac.uk/id/eprint/53973

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