Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Urinary catecholamines and metabolites in the immediate postoperative period following major surgery

Syed, A. A., Wheatley, H. A., Badminton, Michael Norman and McDowell, Ian Frederick 2004. Urinary catecholamines and metabolites in the immediate postoperative period following major surgery. Journal of Clinical Pathology 57 (5) , pp. 548-550. 10.1136/jcp.2003.013201

[img]
Preview
PDF
Download (193kB) | Preview

Abstract

Background: Induction of anaesthesia can precipitate catecholamine release from an undiscovered pheochromocytoma and induce a hypertensive crisis. However, it is assumed that catecholamine and metabolite values resulting from the effects of surgery per se in the early postoperative period would overlap with the values generated by a tumour, and it is not known how soon after biochemical investigations can be carried out. Aim: To study patterns of urinary catecholamine excretion and the feasibility of biochemical screening for phaeochromocytomas in the immediate postoperative period in otherwise healthy subjects undergoing a single type of major surgical procedure. Methods: Catecholamines and metabolites were measured for each mole of creatinine in single voided urine on one preoperative and four postoperative days in five subjects who underwent elective coronary artery bypass graft surgery with an uncomplicated postoperative course. Reference ranges were established from 33 healthy normotensive volunteers. Results: Excretion of adrenaline, noradrenaline, dopamine, vanillylmandelic acid, and metadrenaline was within normal limits. Normetadrenaline excretion was mildly raised in four patients, but did not exceed 1.5 times the upper reference limit, and returned to normality by the fourth postoperative day. Conclusion: It is feasible to perform simple urinary screening for possible phaeochromocytoma in the immediate postoperative period.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
ISSN: 00219746
Last Modified: 04 Jun 2017 01:30
URI: http://orca.cf.ac.uk/id/eprint/54

Citation Data

Cited 4 times in Google Scholar. View in Google Scholar

Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics