Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The genetics and epidemiology of myopia in the ALSPAC cohort

McMahon, George 2011. The genetics and epidemiology of myopia in the ALSPAC cohort. PhD Thesis, Cardiff University.

[img] PDF - Accepted Post-Print Version
Download (10MB)

Abstract

An aim of this thesis is to map a genetic factor that is related to myopia progression. A genome-wide association study of myopia, refractive error and two ocular determinants of refractive error, axial length and corneal curvature was undertaken. A number of genetic locations were identified and extra genotyping and replication in an independent cohort is underway. A further aim of this thesis is investigation of an environmental risk factor of myopia. Epidemiological analyses of two myopia risk factors were undertaken; one in the ALSPAC cohort, another in a cohort from Northern England. In both cases, a relationship with myopia was identified and a plausible mechanism for the relationship is discussed.

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Optometry and Vision Sciences
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RE Ophthalmology
Funders: National Eye Research Centre
Date of First Compliant Deposit: 30 March 2016
Last Modified: 19 Mar 2016 23:29
URI: http://orca.cf.ac.uk/id/eprint/54159

Actions (repository staff only)

Edit Item Edit Item