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Proteoglycans in the corneal stroma and their role in development and pathology

Palka, Barbara Paulina 2010. Proteoglycans in the corneal stroma and their role in development and pathology. PhD Thesis, Cardiff University.

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Transmission electron microscopy of a human cornea with excess chondroitin sulphate/dermatan sulphate glycosaminoglycan showed that changes in proteoglycan structure, content and sulphation lead to the formation of abnormally large collagen fibrils. The lack of sulphation of keratin sulphate in MCD also led to abnormally large fibrils, which are present in the deep stromal layers. These findings suggest overlapping roles of the two proteoglycan populations in the corneal stroma with possible feedback mechanisms, too. Taken together, the findings of this thesis indicate the central role played by proteoglycan-collagen interactions in the development and maintenance of properly formed corneal stroma.

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Date of First Compliant Deposit: 30 March 2016
Last Modified: 25 Oct 2017 14:09

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