Ocular morphology in people with Down's syndrome

Ji, Ping 2006. Ocular morphology in people with Down's syndrome. PhD Thesis, Cardiff University.

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Abstract

The study describes the morphology of eyes in children and adults with Down's syndrome (DS) including ocular biometric parameters (axial length, cornea, anterior chamber, lens and pupil size) and retinal features. There was no significant difference in the correlation of axial length and refraction between DS children (n=46) and controls (n=50). Children with DS (n=18) and adults with DS (n=10) have significantly thinner corneas both in the centre and periphery, smaller corneal radius, higher corneal power, higher corneal aberration and lower lens power compared to their respective control children (n=28) and adults (n=16). Further, in spite of abnormal ocular parameters, refraction in people with DS appeared to be determined by a similar correlation between those parameters as in controls. A larger disc and rim were found in children with DS (n=17) compared to controls (n=28). An increased number of vessels were found in periphery of the retina in children with DS. However, there was a similar distribution of retinal vessels in DS children (n=31) and controls (n=40). The presence of the peripapillary atrophy in children (67%) was much higher than that of controls (28%). No significant correlation was found between the total number of vessels and visual function such as refraction, visual acuity and accommodation among children with DS. Keratoconus was present in 8 adults with DS, however, no keratoconus was found in children with DS but abnormal corneal topography was more common in children with DS compared to that in controls

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Optometry and Vision Sciences
Subjects:	R Medicine > RE Ophthalmology
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 Feb 2016 23:14
URI:	https://orca.cardiff.ac.uk/id/eprint/55448

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