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Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra

Garcia-Reitboeck, Pablo, Anichtchik, Oleg, Dalley, Jeffrey W., Ninkina, Natalia, Tofaris, George K., Buchman, Vladimir L. and Spillantini, Maria Grazia 2013. Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. Experimental Neurology 248 , pp. 541-545. 10.1016/j.expneurol.2013.07.015

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Abstract

The presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies. We show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deletion of the α-synuclein gene or C57Bl/6J mice with a targeted deletion of the α-synuclein gene. This effect of α-synuclein on dopaminergic neuron occurs during development between E10.5 and E13.5 and persists in adult life supporting the involvement of α-synuclein in the development of a subset of dopaminergic neurons.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: α-Synuclein; Dopaminergic; Embryonic development; Parkinson's disease; Transgenic mouse
Publisher: Elsevier
ISSN: 0014-4886
Last Modified: 16 Dec 2018 23:17
URI: http://orca.cf.ac.uk/id/eprint/56909

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