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Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion

Brennan, Sarah C., Davies, Thomas S., Schepelmann, Martin and Riccardi, Daniela 2014. Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion. British Journal of Nutrition 111 (S1) , S16-S22. 10.1017/S0007114513002250

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Abstract

The extracellular Ca-sensing receptor (CaSR) is a sensor for a number of key nutrients within the body, including Ca ions (Ca2+) and l-amino acids. The CaSR is expressed in a number of specialised cells within the gastrointestinal (GI) tract, and much work has been done to examine CaSR's role as a nutrient sensor in this system. This review article examines two emerging roles for the CaSR within the GI tract – as a mediator of kokumi taste modulation in taste cells and as a regulator of dietary hormone release in response to l-amino acids in the intestine.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QR Microbiology
Uncontrolled Keywords: Calcium-sensing receptor; Nutrient-sensing; Amino acids; Gastrointestinal tract; Taste modulation; Taste receptors
Additional Information: Published online before print 2 Jan 2014.
Publisher: Nuitrition Society
ISSN: 0007-1145
Funders: BBSRC, Marie Curie ITN
Date of First Compliant Deposit: 30 March 2016
Last Modified: 16 Mar 2019 22:26
URI: http://orca.cf.ac.uk/id/eprint/56980

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Cited 19 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 6 times in Web of Science. View in Web of Science.

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