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Amyloid precursor protein mRNA levels in the mononuclear blood cells of Alzheimer's and Down's patients

Buckland, Paul Robert, Tidmarsh, Simon, Spurlock, Gillian, Kaiser, Fawad, Yates, Martin, O'Mahony, Gerald and McGuffin, Peter 1993. Amyloid precursor protein mRNA levels in the mononuclear blood cells of Alzheimer's and Down's patients. Molecular Brain Research 18 (4) , pp. 316-320. 10.1016/0169-328X(93)90095-7

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Amyloid precursor protein (APP) is expressed by many non-neural tissues and it is possible that over-expression of the APP gene in non-neural tissue is responsible for the deposition of amyloid β-protein in the brain and elsewhere. One possible source of β-protein is circulating mononuclear blood cells which have previously been shown to express APP. To test this hypothesis. RNA was isolated from the mononuclear blood cells of patients suffering from Alzheimer's disease (n = 27), Down's syndrome (n = 13), senile dementia non-Alzheimer type (n = 14) and from normal individuals (n = 48). The relative abundance of mRNA coding for different splicing variants of the amyloid precursor protein (APP) mRNA was measured using multiprobe oligonucleotide solution hybridisation (MOSH). There was no significant difference in APP mRNA levels between any of the groups. This indicates that Alzheimer's disease is not characterised by an increase in production of APP in circulating mononuclear blood cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
Uncontrolled Keywords: Alzheimer's disease; Amyloid precursor protein; Amyloid β-protein; mRNA level; Mononuclear blood cell
Publisher: Elsevier
ISSN: 0169-328X
Last Modified: 05 Feb 2020 03:35

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