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Association analysis of the proneurotensin gene and bipolar disorder

Austin, J., Hoogendoorn, Bastiaan, Buckland, Paul Robert, Jones, Ian Richard, McCandless, F., Williams, Nigel Melville, Middle, F., Owen, Michael John, Craddock, Nicholas John and O'Donovan, Michael Conlon 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10 (1) , pp. 51-54. 10.1097/00041444-200010010-00009

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Abstract

Neurotensin (NT) localizes within dopaminergic neurones in the mesocortical, mesolimbic and nigrostriatal systems, and it is now clear that NT can selectively modulate dopaminergic neurotransmission. It has therefore been proposed that altered NT function might contribute to the pathogenesis of neuropsychiatric disorders in which disordered dopaminergic neurotransmission is suspected. We have previously screened the gene encoding NT in a sample of schizophrenic and bipolar subjects, and identified three sequence variants. These have now been tested for association with bipolar disorder using a case-control sample of unrelated bipolar subjects and matched controls. No evidence for association was found, and our data therefore suggest that sequence variation in this gene does not make an important contribution to susceptibility to bipolar disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: polymorphism; mutation; gene; schizophrenia; bipolar disorder
Publisher: Lippincott Williams & Wilkins
ISSN: 0955-8829
Last Modified: 16 Sep 2018 22:59
URI: http://orca.cf.ac.uk/id/eprint/57457

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