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Identification and characterization of a novel gene encoding a SEREX antigen in chronic myeloid leukaemia

Rogers, Sarah A., Bowen, Derrick John, Ling, Min, Thomson, Peter, Wang, Zhiqing and Lim, Seah H. 2002. Identification and characterization of a novel gene encoding a SEREX antigen in chronic myeloid leukaemia. British Journal of Haematology 119 (1) , pp. 112-114. 10.1046/j.1365-2141.2002.03775.x

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Abstract

The novel gene encoding Clone 4, previously isolated through the Serological screening of recombinant expression cDNA library (SEREX) in chronic myeloid leukaemia (CML), was characterized. It is localized to chromosome 7 at q22, occupies approximately 4.5 kb of DNA and comprises 4 exons. Three single nucleotide polymorphisms and a 13 base deletion/insertion polymorphism have been identified. The mRNA transcript was approximately 2.4 kb and contained a long 5'-untranslated region of almost 1 kb before the candidate open reading frame. Northern blot analysis and multiple tissue expression array indicated a restricted normal tissue distribution. Our findings provide a platform for future investigations into the role of the gene product in CML.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine
Uncontrolled Keywords: SEREX; chronic myeloid leukaemia; B-cell responses
Additional Information: Short report
Publisher: Wiley-Blackwell
ISSN: 0007-1048
Last Modified: 04 Jun 2017 06:13
URI: http://orca.cf.ac.uk/id/eprint/57474

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