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An influence of ABO blood group on the rate of proteolysis of von Willebrand factor by ADAMTS13

Bowen, Derrick John 2003. An influence of ABO blood group on the rate of proteolysis of von Willebrand factor by ADAMTS13. Journal of Thrombosis and Haemostatis 1 (1) , pp. 33-40. 10.1046/j.1538-7836.2003.00007.x

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Abstract

The susceptibility of von Willebrand factor (VWF) of blood group O, A, B and AB to proteolysis by the ADAMTS13 metalloprotease was investigated. Multimeric analysis indicated that the rate of VWF proteolysis differed between blood groups and was greater for group O VWF than for non-O VWF in the rank order O >/= B > A >/= AB. Measurement of the collagen binding activity of VWF of each blood group following proteolysis for a fixed time interval corroborated the results obtained on multimer analysis: the loss of collagen binding activity was greater for VWF of group O compared with non-O VWF, in the rank order O >/= B > A >/= AB. Ristocetin was found to increase the rate of VWF proteolysis approximately two-fold; the differential between blood groups was retained in the presence of ristocetin.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: ABO blood-group system; blood proteins; endopeptidases; von Willebrand disease; von Willebrand factor
Publisher: Wiley-Blackwell
ISSN: 1538-7933
Last Modified: 04 Jun 2017 06:13
URI: http://orca.cf.ac.uk/id/eprint/57516

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