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Thyrotropin receptor antibodies

Rees Smith, Bernard, Creagh, E. M., Hashim, F. A., Howells, Roger David, Davies Jones, E., Kajita, Y., Buckland, Paul Robert and Petersen, V. B. 1985. Thyrotropin receptor antibodies. Arzneimittelforschung 35 (12A) , pp. 1943-1948.

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Abstract

The thyrotropin (TSH) receptor is an integral membrane protein which contains 2 subunits linked by a disulphide bridge. The A subunit (mol. wt. 50,000) is water soluble and forms the binding site for TSH, whereas the B subunit (mol. wt. 30,000) penetrates the lipid bilayer and probably forms the site for interaction with adenylate cyclase. Autoantibodies to the TSH receptor are found in the sera of patients with Graves' disease. The antibodies bind to the same region of the receptor's A subunit as TSH and usually act as TSH agonists, causing hyperthyroidism. Occasionally, TSH receptor autoantibodies are found which can act as TSH antagonists. Isoelectric focusing and binding studies indicate that these antibodies also bind to the same region of the receptor A subunit as TSH.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Animals; Autoantibodies/analysis; Humans; Hyperthyroidism/diagnosis; Hyperthyroidism/immunology; Isoelectric Focusing, Receptors; Cell Surface/immunology; Receptors; Thyrotropin; Substances; Autoantibodies; Receptors; Cell Surface; Receptors; Thyrotropin
Publisher: Georg Thieme Verlag
ISSN: 0004-4172
Related URLs:
Last Modified: 05 Feb 2020 03:38
URI: http://orca.cf.ac.uk/id/eprint/57783

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