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Altered hippocampal synaptic potentiation in P2X(4) knock-out mice

Sim, Joan A., Chaumont, Severine, Jo, Jihoon, Ulmann, Lauriane, Young, Mark Thomas, Cho, Kwangwook, Buell, Gary, North, R. Alan and Rassendren, Francois 2006. Altered hippocampal synaptic potentiation in P2X(4) knock-out mice. Journal of Neuroscience 26 (35) , pp. 9006-9009. 10.1523/JNEUROSCI.2370-06.2006

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Abstract

P2X4 purinergic receptors are calcium-permeable, ATP-activated ion channels. In the CA1 area of the hippocampus, they are located at the subsynaptic membrane somewhat peripherally to AMPA receptors. The possible role of P2X4 receptors has been difficult to elucidate because of the lack of selective antagonists. Here we report the generation of a P2X4 receptor knock-out mouse and show that long-term potentiation (LTP) at Schaffer collateral synapses is reduced relative to that in wild-type mice. Ivermectin, which selectively potentiates currents at P2X4, was found to increase LTP in wild-type mice but had no effect in P2X4 knock-out mice. We suggest that calcium entry through subsynaptic P2X4 receptors during high-frequency stimulation contributes to synaptic strengthening.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: LTP; P2X4 ; knock-out; mice; hippocampus; ivermectin
Additional Information: Full-text pdf uploaded in accordance with publisher policy as at http://www.jneurosci.org/site/misc/ifa_policies.xhtml (accessed 03/03/2014).
Publisher: Society for Neuroscience
ISSN: 0270-6474
Date of First Compliant Deposit: 30 March 2016
Last Modified: 02 May 2019 12:12
URI: http://orca.cf.ac.uk/id/eprint/57840

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