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No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder

Guy, Carol, Bowen, Timothy, Williams, Nigel Melville, Jones, I. R., McCandless, F, McGuffin, P, Owen, Michael John, Craddock, Nicholas John and O'Donovan, Michael Conlon 1999. No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder. American Journal of Medical Genetics 88 (1) , pp. 57-60. 10.1002/(sici)1096-8628(19990205)88:1%3C57::aid-ajmg10%3E3.0.co;2-6

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Abstract

A recent case-control study suggested that modest enlargements of a CAG repeat in the hKCa3 potassium channel may be associated with bipolar disorder. We tried to replicate this result in a UK Caucasian sample of 203 DSM-IV bipolar I disorder patients and 206 controls group-matched for age and sex. Using the same model of analysis as the earlier study, bipolar probands did not have a higher frequency of alleles with greater than 19 repeats than controls (chi2 = 1.44, 1 df, P = 0.23). Similarly, comparison of the distributions of repeat sizes between probands and controls did not approach statistical significance (Mann-Whitney U test, P = 0.35). We conclude that our data provide no support for the hypothesis that variation at the hKCa3 gene contributes to susceptibility to bipolar disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Adult, Alleles, Bipolar Disorder / etiology, Bipolar Disorder / genetics*, Case Control Studies, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Potassium Channels / genetics*, Potassium Channels, Calcium Activated*, Small Conductance CalciumActivated Potassium Channels, Trinucleotide Repeats / genetics* Substances KCNN3 protein, human Potassium Channels Potassium Channels, Calcium-Activated Small-Conductance Calcium-Activated Potassium Channels
Additional Information: Publication Types Research Support, Non-U.S. Gov't Grant Support G9309834/Medical Research Council/United Kingdom Wellcome Trust/United Kingdom Full Text Sources John Wiley & Sons, Inc. Other Literature Sources COS Scholar Universe Medical Bipolar Disorder - MedlinePlus Health Information Miscellaneous NCI CPTC Antibody Characterization Program
ISSN: 0148-7299
Last Modified: 17 May 2018 18:35
URI: http://orca.cf.ac.uk/id/eprint/57954

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