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Abnormal TCR V/3 repertoire in patients with chronic myeloid leukaemia

Coleman, Sharon Louise, Perera, P., Fisher, Janet, Hoy, Terry, Burnett, Alan Kenneth and Lim, S. H. 1995. Abnormal TCR V/3 repertoire in patients with chronic myeloid leukaemia. British Journal of Haematology 90 (2) , pp. 358-363. 10.1111/j.1365-2141.1995.tb05159.x

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We have used 25 sets of oligonucleotide primers specific for the 24 known major human T-cell receptor (TCR) V/? families in polymerase chain reactions to analyse the T-cell repertoire of the peripheral blood in seven patients with chronic myeloid leukaemia (CML). In contrast to normal healthy individuals, all seven patients exhibited variable degrees of TCR V/3-specific T-cell deletion, ranging from two to eight of the 24 major families. T cells bearing V/3 17 and 8 were most commonly deleted. These results suggest a superantigen effect associated with CML. The patterns of deletion did not appear to correlate with either of the two bcr-abl transcripts. The reason and aetiological agent responsible for the T-cell deletion remain speculative. Further work is ongoing to characterize this phenomenon in animal models and patients with CML.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: CML; TCR V/3 repertoire; deletion
Publisher: Wiley-Blackwell
ISSN: 0007-1048
Last Modified: 10 Oct 2017 15:35

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