Genomic characterization of molluscum contagiosum virus type 1: Identification of the repetitive DNA sequences in the viral genome

Bugert, Joachim Jakob ORCID: https://orcid.org/0000-0002-0556-3211, Rösen-Wolff, Angela and Darai, Gholamreza 1989. Genomic characterization of molluscum contagiosum virus type 1: Identification of the repetitive DNA sequences in the viral genome. Virus Genes 3 (2) , pp. 159-173. 10.1007/BF00125128

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Abstract

The genomes (188 kbp) of the prototypeMolluscum contagiosum virus type 1 (MCV-1) and a variant strain (MCV-1v) were characterized by construction of the physical maps of the viral DNA for the restriction enzymesBamHI,ClaI,EcoRI, andHindIII using a defined gene library harboring the DNA sequences of the MCV-1 genome and by DNA-DNA hybridizations. It was found that the genomes of both MCV strains are identical, with the exception of very few changes in the DNA fragmentation patterns of restriction endonucleaseBamHI as a consequence of naturally occurring nucleotide exchanges in the genome of the variant strain. Detailed hybridization experiments revealed the existence of repetitive DNA sequences, which are located within the terminal regions of the viral genome at the map coordinates 0 to 0.027 and 0.973 to 1.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > R Medicine (General)
Publisher:	Springer
ISSN:	0920-8569
Last Modified:	25 Oct 2022 09:18
URI:	https://orca.cardiff.ac.uk/id/eprint/58028

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