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New avenues in the design and potential application of metal complexes for photodynamic therapy

Stacey, Oliver J. and Pope, Simon J. A. 2013. New avenues in the design and potential application of metal complexes for photodynamic therapy. RSC Advances 3 (48) , pp. 25550-25564. 10.1039/c3ra45219k

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Abstract

Photodynamic therapy (PDT) requires a photosensitizing agent, which can undergo visible light activation, yielding reactive oxygen species and/or radical species. The key physical properties and desirable attributes of established PDT photosensitizer agents are discussed, together with a consideration of the role that photoactive metal coordination complexes may have in the future design of such agents. A number of classes of metal complex are included with a focus upon their ability to generate singlet oxygen, and prior indications of biological utility, compatibility and cytotoxicity through cellular imaging work and DNA binding behaviour.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: RSC Publishing
ISSN: 2046-2069
Last Modified: 04 Jun 2017 06:17
URI: http://orca.cf.ac.uk/id/eprint/58143

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