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Metagenomics and novel gene discovery: promise and potential for novel therapeutics

Culligan, Eamonn P., Sleator, Roy D., Marchesi, Julian Roberto and Hill, Colin 2014. Metagenomics and novel gene discovery: promise and potential for novel therapeutics. Virulence 5 (3) , pp. 1-14. 10.4161/viru.27208

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Abstract

Metagenomics provides a means of assessing the total genetic pool of all the microbes in a particular environment, in a culture-independent manner. It has revealed unprecedented diversity in microbial community composition, which is further reflected in the encoded functional diversity of the genomes, a large proportion of which consists of novel genes. Herein, we review both sequence-based and functional metagenomic methods to uncover novel genes and outline some of the associated problems of each type of approach, as well as potential solutions. Furthermore, we discuss the potential for metagenomic biotherapeutic discovery, with a particular focus on the human gut microbiome and finally, we outline how the discovery of novel genes may be used to create bioengineered probiotics.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: metagenomics, functional metagenomics, novel gene discovery, gut microbiome, microbiota, biotherapeutics, metabiotechnology, bioengineered probiotics
Publisher: Landes Bioscience
ISSN: 2150-5594
Funders: SFI Ireland
Date of Acceptance: 14 November 2013
Last Modified: 21 Feb 2019 16:47
URI: http://orca.cf.ac.uk/id/eprint/58160

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