Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A randomized trial of specialist genetic assessment: psychological impact on women at different levels of familial breast cancer risk

Brain, Katherine Emma ORCID: https://orcid.org/0000-0001-9296-9748, Norman, P., Gray, Jonathon, Rogers, C., Mansel, Robert Edward ORCID: https://orcid.org/0000-0002-8051-0726 and Harper, Peter 2002. A randomized trial of specialist genetic assessment: psychological impact on women at different levels of familial breast cancer risk. British Journal of Cancer 86 (2) , pp. 233-238. 10.1038/sj.bjc.6600051

Full text not available from this repository.

Abstract

The aim was to compare the psychological impact of a multidisciplinary specialist genetics service with surgical provision in women at high risk and those at lower risk of familial breast cancer. Women (n=735) were randomized to a surgical consultation with (trial group) or without (control group) specialist genetic risk assessment and the possible offer of presymptomatic genetic testing. Participants completed questionnaires before and immediately after the consultation to assess anxiety, cancer worry, perceived risk, interest in genetic testing and satisfaction. Responses of subgroups of women stratified by clinicians as low, moderate, or high risk were analyzed. There were no significant main effects of study intervention on any outcome variable. Regardless of risk information, there was a statistically significant reduction in state anxiety (P<0.001). Reductions in cancer worry and perceived risk were significant for women at low or moderate risk (P<0.001) but not those at high risk, and satisfaction was significantly lower in the high risk group (P<0.001). In high risk women who received specialist genetic input, there was a marginally significant trend towards increased perceived risk. The effect of risk information on interest in genetic testing was not significant. Breast care specialists other than geneticists might provide assessments of breast cancer risk, reassuring women at reduced risk and targeting those at high risk for specialist genetic counselling and testing services. These findings are discussed in relation to the existing UK Calman-Hine model of service delivery in cancer genetics. DOI: 10.1038/sj/bjc/6600051 www.bjcancer.comCopyright 2002 The Cancer Research Campaign

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Adult,Aged,Breast Neoplasms/etiology,Breast Neoplasms/genetics*,Breast Neoplasms/psychology*,Female,Genetic Counseling*,Genetic Testing/psychology*,Humans,Middle Aged,Patient Satisfaction,Risk Assessment,Stress, Psychological*
Additional Information: Publication Types Clinical Trial Randomized Controlled Trial Full Text Sources Nature Publishing Group EBSCO Europe PubMed Central ProQuest PubMed Central PubMed Central Canada Medical Breast Cancer - MedlinePlus Health Information Genetic Counseling - MedlinePlus Health Information Genetic Testing - MedlinePlus Health Information Stress - MedlinePlus Health Information
Publisher: Nature Publishing Group
ISSN: 0007-0920
Last Modified: 04 Mar 2023 03:07
URI: https://orca.cardiff.ac.uk/id/eprint/58283

Citation Data

Cited 61 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item