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Adverse impact of bone marrow transplantation on quality of life in acute myeloid leukaemia patients

Watson, M., Buck, G., Wheatley, K., Homewood, J. R., Goldstone, A. H., Rees, J. K. H. and Burnett, Alan Kenneth 2004. Adverse impact of bone marrow transplantation on quality of life in acute myeloid leukaemia patients. European Journal of Cancer 40 (7) , pp. 971-978. 10.1016/S0959-8049(03)00628-2

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The increasing success of intensive consolidation chemotherapy (CCT) as an alternative to bone marrow transplant (BMT) in acute myeloid leukaemia (AML) necessitates comparison of the impact on quality of life (QoL) of these two treatment modalities. Most QoL studies following BMT involve small patient numbers and provide ambivalent results. The present study examines QoL in a large number of patients 1 year from the end of treatment within the United Kingdom Medical Research Council (UK MRC) AML10 trial of BMT versus CCT. Allogeneic-BMT (Allo-BMT) was observed to have an adverse impact on most QoL dimensions compared with Autologous-BMT (A-BMT) and CCT. More patients receiving BMT had mouth dryness problems and worse sexual and social relationships, professional and leisure activities than CCT patients. QoL in A-BMT patients was less impacted than Allo-BMT. Intention-to-treat analysis showed similar results. These results indicate that a reconsideration of treatment strategies is warranted, and that further, good prospective studies are needed to evaluate more clearly the effects of these treatments in long-term survivors.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Quality of life,acute myeloid leukaemia,bone marrow transplantation,MRC AML 10 trial
Publisher: Elsevier
ISSN: 0014-2964
Last Modified: 25 Jun 2017 04:41

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