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Recent advances in molluscum contagiosum virus research

Bugert, Joachim Jakon and Darai, G. 1997. Recent advances in molluscum contagiosum virus research. In: Kaaden, Oskar-Ruger, Czerny, Claus-Peter and Eichhorn, Werner eds. Viral zoonoses and food of animal origin : a re-evaluation of possible hazards for human health, New York, NY: Springer, pp. 35-47. (10.1007/978-3-7091-6534-8_4)

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Abstract

Molluscum contagiosum virus (MCV) and variola virus (VAR) are the only two poxviruses that are specific for man. MCV causes skin tumors in humans and primarily in children and immunocompromised individuals. MCV is unable to replicate in tissue culture cells or animals. Recently, the DNA sequence of the 190 kbp MCV genome was reported by Senkevich et al. MCV was predicted to encode 163 proteins of which 103 were clearly related to those of smallpox virus. In contrast, it was found that MCV lacks 83 genes of VAR, including those involved in the suppression of the host response to infection, nucleotide biosynthesis, and cell proliferation. However, MCV possesses 59 genes predicted to code for novel proteins including MHC-class I, chemokine and glutathione peroxidase homologs not found in other poxviruses. The MCV genomic data allow the investigation of novel host defense mechanisms and provide new possibilities for the development of therapeutics for treatment and prevention of the MCV infection.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Animals, Genome, Viral, Humans, Molluscum Contagiosum/diagnosis, Molluscum Contagiosum/epidemiology, Molluscum Contagiosum/therapy, Molluscum Contagiosum/virology*, Molluscum contagiosum virus*/drug effects, Molluscum contagiosum virus*/genetics, Molluscum contagiosum virus*/growth & development, Molluscum contagiosum virus*/isolation & purification Research
Publisher: Springer
ISBN: 9783211830147
ISSN: 0939-1983
Last Modified: 15 Nov 2016 04:54
URI: http://orca.cf.ac.uk/id/eprint/58472

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