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Role for T-type Ca2+ channels in sleep waves

Crunelli, Vincenzo, David, Francois, Leresche, Nathalie and Lambert, Régis C. 2014. Role for T-type Ca2+ channels in sleep waves. Pflugers Archiv European Journal of Physiology 466 (4) , pp. 735-745. 10.1007/s00424-014-1477-3

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Abstract

Since their discovery more than 30 years ago, low-threshold T-type Ca2+ channels (T channels) have been suggested to play a key role in many EEG waves of non-REM sleep, which has remained exclusively linked to the ability of these channels to generate low-threshold Ca2+ potentials and associated high-frequency bursts of action potentials. Our present understanding of the biophysics and physiology of T channels, however, highlights a much more diverse and complex picture of the pivotal contributions that they make to different sleep rhythms. In particular, recent experimental evidence has conclusively demonstrated the essential contribution of thalamic T channels to the expression of slow waves of natural sleep and the key role played by Ca2+ entry through these channels in the activation or modulation of other voltage-dependent channels that are important for the generation of both slow waves and sleep spindles. However, the precise contribution to sleep rhythms of T channels in cortical neurons and other sleep-controlling neuronal networks remains unknown, and a full understanding of the cellular and network mechanisms of sleep delta waves is still lacking.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Additional Information: PDF uploaded in accordance with publisher's policies at http://www.sherpa.ac.uk/romeo/issn/0031-6768/ (accessed 1.4.16). First online: 01 March 2014
Publisher: Springer
ISSN: 0031-6768
Date of First Compliant Deposit: 1 April 2016
Last Modified: 29 Jun 2019 15:55
URI: http://orca.cf.ac.uk/id/eprint/59379

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