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Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients

Llano, I., Gonzalez, J., Caputo, C., Lai, Francis Anthony, Blayney, Lynda Mary, Tan, Y. P. and Marty, A. 2000. Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients. Nature Neuroscience 3 (12) , pp. 1256-1265. 10.1038/81781

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Abstract

The cellular mechanisms responsible for large miniature currents in some brain synapses remain undefined. In Purkinje cells, we found that large-amplitude miniature inhibitory postsynaptic currents (mIPSCs) were inhibited by ryanodine or by long-term removal of extracellular Ca2+. Two-photon Ca2+ imaging revealed random, ryanodine-sensitive intracellular Ca2+ transients, spatially constrained at putative presynaptic terminals. At high concentration, ryanodine decreased action-potential-evoked rises in intracellular Ca2+. Immuno-localization showed ryanodine receptors in these terminals. Our data suggest that large mIPSCs are multivesicular events regulated by Ca2+ release from ryanodine-sensitive presynaptic Ca2+ stores.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Additional Information: There is an Erratum (March 2001) associated with this Article.
ISSN: 1097-6256
Last Modified: 27 Mar 2020 02:38
URI: http://orca.cf.ac.uk/id/eprint/59389

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