Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Potent antimicrobial activity of bone cement encapsulating silver nanoparticles capped with oleic acid

Prokopovich, Polina, Kobrick, Mathias, Brousseau, Emmanuel Bruno Jean Paul and Perni, Stefano 2015. Potent antimicrobial activity of bone cement encapsulating silver nanoparticles capped with oleic acid. Journal of Biomedical Materials Research: Part B - Applied Biomaterials 103 (2) , pp. 273-281. 10.1002/jbm.b.33196

PDF - Published Version
Download (445kB) | Preview


Bone cement is widely used in surgical treatments for the fixation for orthopaedic devices. Subsequently, 2–3% of patients undergoing these procedures develop infections that are both a major health risk for patients and a cost for the health service providers; this is also aggravated by the fact that antibiotics are losing efficacy because of the rising resistance of microorganisms to these substances. In this study, oleic acid capped silver nanoparticles (NP) were encapsulated into Poly(methyl methacrylate) (PMMA)-based bone cement samples at various ratios. Antimicrobial activity against Methicillin Resistant Staphylococcus aureus, S. aureus, Staphylococcus epidermidis, Acinetobacter baumannii was exhibited at NP concentrations as low as 0.05% (w/w). Furthermore, the mechanical properties and cytotoxicity of the bone cement containing these NP were assessed to guarantee that such material is safe to be used in orthopaedic surgical practice.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Engineering
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Uncontrolled Keywords: Bone cement; antimicrobial; silver nanoparticles; nanoindentation; PMMA.
Publisher: Wiley
ISSN: 1552-4981
Funders: ARUK
Date of First Compliant Deposit: 30 March 2016
Last Modified: 19 Oct 2019 03:32

Citation Data

Cited 2 times in Google Scholar. View in Google Scholar

Cited 33 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics